Applied Research Project Capstone Essay Example | Topics and Well Written Essays - 250 words

Applied Research Project Capstone - Essay Example The Department of Homeland Security (2010) also argues that the new and evolving threats that need close attention are cyber security, prevention of cyber crime, and the protection of the critical infrastructure. The article provides information on how through international cooperation there have been efforts to foster the establishment of the national and international watch and warning networks in order to detect and prevent cyber attacks as they emerge. Information on public awareness on cyber security is also found in the article. Besides, there is also information on the need for coordination and cooperation between the government and the private sector to ensure cyber security. The article by the National Institute of Standards and Technology (2014), provides a framework for enhancing critical infrastructure cyber security. Since the United States’ cyberspace is connected to the rest of the world, attacks can cross the border at lightening speed. The article also provides information on the significance of critical infrastructure to the national and economic security of the nation. Moreover, there is information on how internet traffic can be monitored and malicious intrusions to the critical infrastructure systems detected. Department of Homeland Security. (2010). Preventing and Defending Against Cyber Attacks. Retrieved February 26, 2015, from: http://www.dhs.gov/xlibrary/assets/defending-against-cyber-attacks-november-2010.pdf National Institute of Standards and Technology. (2014). Framework for Improving Critical Infrastructure Cyber Security. Retrieved February 26, 2015, from

Pheochromocytoma Essay Example | Topics and Well Written Essays - 4250 words

Pheochromocytoma - Essay Example They are usually derived from the adrenal medulla but may develop from chromaffin cells in or about sympathetic ganglia (pheochromocytomas or paragangliomas). The mechanism of catecholamine release is not well documented. It is suspected that the tumor may be caused by the changes in blood flow and necrosis within the tumor. The tumors do not contain nerves and therefore neural stimulation will not trigger catecholamine release. They also store and secrete a variety of peptides, such as endogenous opioids, neuropeptide Y, and chromagranin, which may contribute to the clinical manifestation in selected cases. The term pheochromocytoma was coined by a pathologist named Pick after the Greek work phaios, meaning dark or dusky, and chroma, meaning color - to describe the chromaffin reaction seen in adrenomedullary tumors. The term is mostly used to refer to tumors that arise from the adrenal medulla. Pheochromocytoma's most common manifestation is hypertension. Spectacular and alarming hypertensive paroxysms or crises may occur in over half the cases. Although they only occur in .1% of the hypertensive population, it is nevertheless a significant cause of high blood pressure and is correctible, if properly diagnosed and treated. If it is ignored, then it could be fatal and will put patients at risk for a lethal hypertensive paroxysm and long-term sequelae (a pathological condition resulting from a prior disease, injury or attack) of the disease. It is also an indication of the presence of a familiar disorder. An early detection may reduce the risk of metastasis. Description Pheochromocytoma is a rare disease in which tumors form in chromaffin cells of the body. Most pheochromocytomas, about 98% of the time, start inside the adrenal glands (adrenal medulla). It is a tumor which is made up of large, polyhedral, pleomorphic chromaffin cells, which is only malignant in less than 10% of the case, and which causes the adrenal glands to produce too much adrenaline. The histologic appearance will not show malignancy. A local invasion of the surrounding tissue or distant metastases will reveal malignancy. It usually affects only one of the adrenal glands, although it may also start in other parts of the body, such as the area around the heart or bladder. Pathology Statistically, pheochromocytoma occur in 1-2 out of 100,000 adults, around 80% of which are unilateral and solitary, only 10% are bilateral, and the remaining 10% are extraadrenal. Majority of these cases, about 80-90% are sporadic, and the remaining are connected to hereditary syndromes (.eg. multiple endocrine neoplasia). In pediatric patients, about are bilateral and another are extraadrenal. For yet unexplained reason, lesions are usually in the right side. Most pheochromocytomas are small, weighing less than 100 grams and are about 10 cm in diameter. They may however grow to over 3 kg in size. The tumors have vessels or ducts, or are highly vascular. Extraadrenal pheochromocytomas usually weigh 20-40 g and are less than 5 cm in diameter. Most are located within the abdomen in association with the celiac, superior mesenteric ganglia. Approximately 1% are in the thorax, 1 percent are within the urinary bladder, and less than 1% are in the neck, usually in association with the sympathetic ganglia or the extracranial branches of the ninth or tenth cranial nerves. Clinical Features Most of pheochromocytomas